S100A8 and S100A9 in saliva, blood and gingival crevicular fluid for screening established periodontitis: a cross-sectional study

Abstract Background Periodontitis is one of major oral diseases, which has no consensus on early screening tool. This study aimed to compare the association and ability S100A8 S100A9 in saliva, blood gingival crevicular fluid (GCF) for periodontitis status. Methods We recruited 149 community Korean adults, 50 or initial (NIPERIO) 99 established (PERIO). Using clinical attachment loss a panoramic radiograph, stage II–IV new classification proposed at 2018 was considered cases as PERIO. Enzyme linked immunosorbent assay kit used quantify S100A9. T-test, analysis covariance, Mann–Whitney test correlation were applied relationship blood, GCF periodontitis. Receiver operating characteristic curve ability. Results Among GCF, saliva significantly higher PERIO than NIPERIO ( p < 0.05). However, The salivary 75% PERIO, while that 74% NIPERIO. Salivary positively correlated Conclusion could be potential diagnostic marker useful